αvβ3 integrin — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T6812L	Cyclo(-RGDfK) TFA		Integrin
	Cyclo(-RGDfK) is a selective αvβ3 integrin inhibitor(IC50 : 0.94 nM).		Integrin
T6812	Cyclo(-RGDfK)	Cyclo (-RGDfK)	Integrin
	Cyclo(-RGDfK) (Cyclo (-RGDfK)) is an effective and specific αvβ3 integrin inhibitor.		Integrin
TP1474	LXW7		Integrin
	LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (ECs) targeting ligand. LXW7 is a disulfide cyclic octa-pepti...		Integrin
TP1879L1	P11 acetate		Integrin
	P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).		Integrin
T6813	Cyclo(RGDyK) trifluoroacetate	Cyclo(RGDyK)	Integrin
	Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.		Integrin
T6657	SB273005		Integrin
	SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.		Integrin
T2494	Cilengitide	EMD 121974	Integrin , Autophagy
	Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.		Integrin , Autophagy
T36715	Tetrac	Tetraiodothyroacetic acid,3,3',5,5'-Tetraiodothyroacetic acid	Apoptosis , EGFR
	Tetrac (Tetraiodothyroacetic acid) is a derivative of L-thyroxine (T4), a thyroxine integrin receptor antagonist.Tetrac induces antiproliferation by blocking EGFR-mediated cell signaling in colorectal cancer cells.Tetrac...		Apoptosis , EGFR
TP1459L	Gly-Arg-Gly-Asp-Ser acetate(96426-21-0 free base)		Integrin
	Gly-Arg-Gly-Asp-Ser (GRGDS) acetate is a cell binding protein domain derived from the cell-binding region of fibronectin.		Integrin
TQ0250	CWHM-12		Integrin
	CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).		Integrin
TP2148	LXW7 TFA (1313004-77-1 free base)	LXW7 TFA	Integrin
	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3 integrin (IC50: 0.68 μM). It increases the phosphorylation...		Integrin
T16085	MK-0429	L-000845704	Others
	MK-0429 is an orally active, selective, and nonpeptide antagonist of αvβ3 integrin (IC50: 80 nM).		Others
TP2390	Maraciclatide	NC-100692,NC 100692,NC100692
	Maraciclatide is a radiopharmaceutical targeting αvβ3 integrin.
T8726	Cyclo(RGDyK)		Integrin
	Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.		Integrin
T15584	Integrin Antagonists 27		Others
	Integrin Antagonists 27 is a small molecule integrin αvβ3 antagonist. It has a binding affinity of 18 nM and as a novel anticancer agent.		Others
T69460	TSRI265
	TSRI265 is a novel αvβ3 ligand, disrupting the integrin-MMP2 interaction and showing antiangiogenic activit, inhibiting angiogenesis and tumor growth in vivo.
T11663	Integrin-IN-2		Others
	Integrin-IN-2 is an orally bioavailable pan αv integrin inhibitor.Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively.		Others
T68462	D-Ornithine lactam
	D-Ornithine lactam is a building block. It has been used in the synthesis of hepatitis C virus non-structural protein 5B inhibitors, as well as αVβ3 integrin receptor antagonists.
TP1879	HSDVHK-NH2	P11
	Potent antagonist of the integrin αvβ3-vitronectin interaction (IC50 = 25.72 nM). Blocks proliferation and induces apoptosis in HUVECs; antiangiogenic.
T6806	Cilengitide TFA		Integrin , Autophagy
	Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectivity against gpIIbIIIa. Phase 2.		Integrin , Autophagy